2-HYDROXYFORMANILIDE Property

Melting point:

182-183 °C

Boiling point:

338.4±25.0 °C(Predicted)

Density 

1.310±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

DMF: 1 mg/mL,DMSO: 1 mg/mL,PBS (pH 7.2): 0.16 mg/mL

form 

A solid

pka

9.19±0.35(Predicted)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

2-HYDROXYFORMANILIDE Chemical Properties,Usage,Production

Biological Activity

N-formyl-2-Aminophenol is a bacterial secondary metabolite that has been found in P. chrysogenum and has antioxidant activity.1,2 It scavenges DPPH radicals in a cell-free assay with an IC50 value of 3.23 μg/ml.2 N-formyl-2-Aminophenol has also been used in the synthesis of compounds with antibacterial and antifungal activities.3

References

1.Frisvad, J.C., Smedsgaard, J., Larsen, T.O., et al.Mycotoxins, drugs and other extrolites produced by species in Penicillium subgenus PenicilliumStud. Mycol.49201-241(2004) 2.Deepali, A., Akansha, A., Anamika, B., et al.Hydroxylamine hydrochloride as an effective catalyst for form amide derivative synthesis and their DPPH scavenging activityRes. J. Chem. Sci.4(10)54-57(2014) 3.Gupta, S., Verma, P., and Singh, V.Synthesis and antimicrobial study of 2-amino-imidazole derivativesIndian J. Chem. 57B679-686(2018)